Cell Surface Receptors, Volume 68 (Advances in Protein Chemistry)

by Ph.D, K. Christopher Garcia

Publisher: Academic Press

Written in English
Cover of: Cell Surface Receptors, Volume 68 (Advances in Protein Chemistry) | Ph.D, K. Christopher Garcia
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Number of Pages520
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Open LibraryOL7325338M
ISBN 100120342685
ISBN 109780120342686

The BBSome, a complex of eight Bardet-Biedl syndrome (BBS) proteins involved in cilia function, has emerged as an important regulator of energy balance, but the underlying cellular and molecular mechanisms are not fully understood. Here, we show that the control of energy homeostasis by the anorexigenic proopiomelanocortin (POMC) neurons and orexigenic agouti-related peptide (AgRP) .   P2X receptors are membrane ion channels activated by the binding of extracellular adenosine triphosphate (ATP). For years their functional significance was . Structure-Function Relations for Cell Surface Receptors and Adenylate Cyclase: Studies Using Target Size Analysis of Radiation Inactivation Pages Schlegel, Werner.   TRAIL binds to death receptors (DR4 and DR5) expressed on the surface of a range of cancer cells, which can induce cell apoptosis. TRAIL also binds to three decoy receptors (DcR1, DcR2, DcR3) expressed on the surface of cells, which do not signal apoptosis and can act as competitive inhibitors to apoptosis [ 14 ].

The innate immune response to viral pathogens is critical in order to mobilize protective immunity. Cells of the innate immune system detect viral infection largely through germline-encoded pattern recognition receptors (PRRs) present either on the cell surface or within distinct intracellular compartments. These include the Toll-like receptors (TLRs), the retinoic acid-inducble gene I-like. Vasopressin receptor 2 (V2R), or arginine vasopressin receptor 2 (officially called AVPR2), is a protein that acts as receptor for vasopressin. AVPR2 belongs to the subfamily of G-protein-coupled activity is mediated by the G s type of G proteins, which stimulate adenylate cyclase.. AVPR2 is expressed in the kidney tubule, predominantly in the membrane of cells of the distal. Tumour necrosis factor receptors (TNFR) and the Fas receptor (FasR) have been implicated in the pathogenesis of interstitial lung diseases. The current authors examined the expression of TNFR-1, TNFR-2 and FasR by bronchoalveolar cells in hypersensitivity pneumonitis (HP). Cell surface receptor expression on bronchoalveolar lavage cells was analysed by immunocytochemistry in 11 HP patients, .   Extracellular vesicles (EVs) have in the recent decades gained an important stand as vehicles enabling cell-to-cell transport and communication. With the advanced development towards their clinical use and increasing versatility of potential applications, improving their tissue-specific targeting in order to enhance their functionality in drug delivery opened as a challenging engineering .

The use of various molecular biology and biochemistry techniques, based on chemical crosslinking, e.g., biotin or radioactive labeling, immunofluorescence to label membrane receptors and flow cytometry, allows for quantification of changes of cell surface receptor presentation.   Ligands that binds with receptors on the cell-membrane of immune systems to trigger reactions, signal transductions. Cytokines are secreted by immune cells in response to cellular signaling, and bind to specific membrane receptors, which then signal the cell via second messengers, often tyrosine kinases, to alter cellular activity (gene. Subsequent chase in the presence of excess unlabeled phosphate and phorbol esters lowered [32 P]ATP(i) specific activity by 68% at 1 h. Surface immunoprecipitation during this chase period showed the phosphorylated ASGP receptors were rapidly lost from the cell surface (t(1/2) = 20 min). The receptor determinant of influenza A and B viruses is sialic acid, mostly N-acetyl-neuraminic acid (Neu5Ac).The structures of complexes of HA of influenza A and B viruses with sialyloligosaccharides were determined by X-ray crystallography (reviewed in [15, 16]).The sialic acid-binding site is a shallow pocket located on the globular head of HA (Fig. 1).

Cell Surface Receptors, Volume 68 (Advances in Protein Chemistry) by Ph.D, K. Christopher Garcia Download PDF EPUB FB2

Purchase Cell Surface Receptors, Volume 68 - 1st Edition. Print Book & E-Book. ISBNSearch in this book series. Cell Surface Receptors. Christopher Garcia. Vol Pages () Download full volume. Previous volume. Next volume. Actions for selected chapters. Select all / Deselect all.

Download PDFs Export citations. Show all chapter previews Show all chapter previews. This book is divided into four sections reflecting the subject areas covered during the course of the meeting.

The first section entitled "Membrane Structure and Receptor Function" is intended as an overview of the role of membrane structure in determining the regulatory properties, physical state, structure and location of cell surface receptors. Photoswitching Proteins pp | Cite as.

Photoswitching of Cell Surface Receptors Using Tethered Ligands. Authors; Authors and affiliations; Andreas Reiner; Ehud Y. Isacoff; Protocol. First Online: 21 March 15 Citations; k Downloads; Part of the Methods in Molecular Biology book series (MIMB, volume ) Abstract Cited by:   Y.

Yamaguchi, G. Pearce, C.A. RyanThe cell surface leucine-rich repeat receptor for AtPep1, an endogenous peptide elicitor in Arabidopsis, is functional in transgenic tobacco cells Proc Natl Acad Sci U S A, (), pp. Cited by:   Plants sense chemically different bacterial molecular patterns through different types of plant cell surface receptors.

LRR-type receptors sense proteinaceous MAMPs. Three distinct flagellin epitopes, flg22, flgII, and CD, are sensed through RLK FLS2 in most higher plants, RLK FLS3 in tomato and some other Solanaceae, and an unknown. CD1* MHC-like molecule that presents lipid molecules: CD1a: CD1a (Cluster of Differentiation 1a), or T-cell surface glycoprotein CD1a, is a human protein encoded by the CD1A antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.: CD1b: T-cell surface glycoprotein CD1b.

Buy this book eB68 € price for Spain (gross) Buy eBook the general concept of cell-associated receptors as the molecular entity primarily responsible for the specificity of signal recognition arose independently in Cell Surface Receptors fields of immunology, pharmacology and Volume 68 book biology.

Cell Surface Receptors. Cell Signaling. Cell signaling is the fundamental process by which specific information is transferred from the cell surface to the cytosol and ultimately to the nucleus, leading to changes in gene expression.

From: Handbook of Toxicology of Chemical Warfare Agents, Related terms: Ligand; Eicosanoid Receptor; Enzymes; Apoptosis. The first layer of the plant immune system comprises plasma membrane-localized receptor proteins and intracellular receptors of the nucleotide-binding leucine-rich repeat protein superfamily.

Together, these immune receptors act as a network of surveillance machines in recognizing extracellular and intracellular pathogen invasion-derived molecules, ranging from conserved structural epitopes to. The N-methyl-d-aspartic acid (NMDA) receptor, a glutamate-gated ion channel receptor, has been characterized on the surface of several cancer cell lines.NMDA receptors are heterotetrameric integral membrane proteins constructed from constituent polypeptides that encircle a potential channel, whose opening is gated by the binding and cooperative interaction of l-glutamate.

Introduction. The self-ligand glycoprotein, signaling lymphocyte activation molecule (SLAM or CD), is not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, and macrophages ().SLAM is thought to play an important role in adhesion between T cells and APCs and has been shown to act as a coreceptor in TCR.

Various growth factors and full-length cell surface receptors such as EGFR are translocated from the cell surface to the nucleoplasm, baffling cell biologists to the mechanisms and functions of this process. Elevated levels of nuclear EGFR correlate with poor prognosis in various cancers.

In recent years, nuclear EGFR has been implicated in regulating gene transcription, cell proliferation and. For the CRISPR/Cas9 edited cells used in this work, we confirmed that the fluorescently tagged LRP6 receptors were properly localized at the cell surface (Figure 3—figure supplement 3b and Figure 3—figure supplement 8b) and underwent Wnt-dependent post-translational modification similar to wt receptors (Figure 3—figure supplement 8a).

The liquid content of the cell leaks out due to diffusion. Plasmolysis is extremely rare in nature. In animal cells. In animal cells however, there is no cell wall, and so if the water potential of the solution around the cell is too high, the cell will swell and burst, but if it is too low, the cell shrinks.

In Alzheimer's disease (AD), cell-surface AMPARs are downregulated, however the reason for this downregulation is not clear. In the present study, we found that Aβ significantly decreased levels of the cell-surface AMPA-type glutamate receptor subunit 2 (GluR2), and increased the concentration of free cytosolic calcium ion ([Ca 2+ ] i) in.

A major advance in the biological sciences in the past decade has been the biochemical identification of cell membrane receptors. The existence of re­ ceptor substances on the surface of cells that recognize and bind to extracellular molecules was proposed at the beginning of the century by the pharmacologist and immunologist Paul Ehrlich and the physiologist J.

Langley. Search the world's most comprehensive index of full-text books. My library. A key feature of plants is their plastic development tailored to the environmental conditions. To integrate environmental signals with genetic growth regulatory programs, plants rely on a number of hormonal pathways, which are intimately connected at multiple levels.

Brassinosteroids (BRs), a class of plant sterol hormones, are perceived by cell surface receptors and trigger responses. From the Edited Volume.

and to cell surface adhesion receptors such as integrins. Through their interactions with adhesion receptors (e.g., α5β1 integrin), fibronectins influence the shape and movement of cells and the organization of the cytoskeleton.

Help us write another book on this subject and reach those readers. Suggest a book. By fusing a targeting ligand with high affinity for a given cell surface molecule to the C terminus of H mut, the virus is redirected in cell entry to a receptor of choice.

In this way, a variety of cell surface-exposed tumor antigens have been shown to be functional as MV receptors (20). hpca1, ghr1 (guard cell hydrogen peroxide-resistant1), fls2 (flagellin-sensitive 2), efr (ef-tu receptor), bri1 and bak1 (brassinosteroid insensitive 1-associated receptor kinase 1) are illustrated.

Cell Surface Receptors contains an extensive discussion of cell surface receptors in 11 chapters by experts in their field. As cell surface receptors are involved in almost every aspect of signaling throughout the body, the topic has been of high interest in the community in recent years.

Integrins are heterodimeric cell-surface receptors that consist of α- and β-subunits, such as integrins α v β 3 and α v β 5, and which are barely detectable or entirely absent from normal blood vessels but are abundantly expressed on tumor-associated endothelial cells [].

a, Foci of RSV infection in 1HAEo − cells pre-treated with inhibitors of cell-surface receptors. The results for treatment with inhibitors of other receptors are presented in Figs. 1 e, 2a. In patch 2 (∼ 1 Å 2 buried surface), there is a slightly concaved outer surface at the far end of the MERS-CoV receptor-binding subdomain, formed by the short β6 strand, C-terminal parts.

To determine the effect of the enzymatic removal of different classes of GAGs from cell surface PGs on leptospiral attachment, cell monolayers were incubated at 37°C with a μl/well volume of a lyase (heparinase I, heparitinase, chondroitinase AC, or chondroitinase ABC; Sigma-Aldrich) at U/ml for 2 h in cell medium supplemented with 1%.

Recently, we have found that IL-8 is chemotactic for epidermal cells, and human keratinocytes possess specific receptors for IL-8 (ILR). Since IL-1α and tumor necrosis factor-α (TNF-α) are capable of modulating various cell surface receptors of keratinocytes, we have studied the effects of these cytokines on the ILR expression of human.

In the biological context of organisms' production of gene products, downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external complementary process that involves increases of such components is called upregulation.

An example of downregulation is the cellular decrease in the expression of a. NECA is approximately 10 times more potent than ADO for the A 2B-R, so these data suggest that if to 1 μM NECA is required to regulate ASL volume, then the cell surface ADO concentration must be approximately 1 to 10 μM in native ASL to activate A 2B-R, stimulate CFTR and maintain ASL volume.

Angiotensin-converting enzyme 2 is a zinc containing metalloenzyme located on the surface of endothelial and other cells. ACE2 protein contains an N-terminal peptidase M2 domain and a C-terminal collectrin renal amino acid transporter domain.

ACE2 is a single-pass type I membrane protein, with its enzymatically active domain exposed on the surface of cells in lungs and other tissues.

Accumulation of second messenger IP 3 in W2- and D3-Grm1 clones is specifically induced by Grm1-agonist. Guided by previous studies of G-protein coupled metabotropic glutamate receptor signaling, both in the CNS and in melanoma derived tumor cells [15, 25, 26], functionality of the exogenous receptor was assessed in W2- and D3-Grm1 clones by the accumulation of the .Somatostatin receptors (SSTRs) are present on the cell surface of neuroendocrine cells, providing a unique and specific molecular target for imaging.

Somatostatin is a peptide hormone that binds to this receptor, thereby regulating neurotransmission, hormone secretion, and cell proliferation. Somatostatin generally exerts an.